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There's not enough evidence to know what the effects might be of taking high daily doses of nicotinamide supplements. Women who cannot get pregnant and men should be able to get all the folate they need by eating a varied and balanced diet. Folic acid supplements need to be taken before you get pregnant, so start taking them before you stop using contraception or if there's a chance you might get pregnant. There's not enough evidence to know what the effects might be of taking high doses of thiamin supplements each day. Taking 17mg or less of nicotinic acid supplements a day, or 500mg or less of nicotinamide supplements a day, is unlikely to cause any harm.
Vitamins and minerals - B vitamins and folic acid - NHS Vitamins and minerals - B vitamins and folic acid - NHS
If you're taking folic acid supplements, it's important not to take too much as this could be harmful. The Department of Health and Social Care recommends that folic acid supplements are taken by all women who are pregnant or could get pregnant. This is particularly a concern for older people because it becomes more difficult to absorb vitamin B12 as you get older.
You should be able to get all the pantothenic acid you need from your daily diet, as it's found in many foods.
There's not enough evidence to show what the effects may be of taking high doses of vitamin B12 supplements each day. But in a few cases when people have taken large amounts of vitamin B6, particularly for more than a few months, the effect can be permanent. Most people should be able to get the amount of folate they need by eating a varied and balanced diet. There's not enough evidence to know what the effects might be of taking high daily doses of biotin supplements.Taking doses of folic acid higher than 1mg can mask the symptoms of vitamin B12 deficiency, which can eventually damage the nervous system if it's not spotted and treated. This is important and unlikely to cause harm, as it's taken on a short-term basis, but speak to your doctor first. There's not enough evidence to know what the effects might be of taking high doses of riboflavin supplements each day.