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The single study in this review that achieved fingertip cooling by compression with surgical gloves demonstrated statistically significant benefits with the intervention ( Tsuyuki et al., 2016). It should be noted that it is uncertain to what degree the observed benefit in this study is attributed to a decrease in circulation at target tissues compared with a resulting decrease in temperature. Additional studies are needed to further assess the validity of the findings in the Tsuyuki study and to discern benefit from compression compared with direct cooling. Fingertip cooling by compression offers a promising area for further study given its low cost, ease of application, and seemingly good tolerability. Chemotherapy-induced peripheral neuropathy may be associated with decreased quality of life, reduced functional abilities, and may prevent patients from returning to work ( Miltenburg & Boogerd, 2014; Mols, Beijers, Vreugdenhil, & van de Poll-Franse, 2014; Tofthagen, 2010; Zanville et al., 2016). Functional limitations of CIPN relate to hand pain, hand numbness affecting fine motor skills, and foot pain and numbness, which may cause difficulty walking ( Bhatnagar et al., 2014; Zanville et al., 2016). Symptoms and severity of CIPN are also associated with an increased risk of falls ( Tofthagen, Overcash, & Kip, 2012). Symptoms of CIPN contribute to feelings of depression and loss of purpose when patients lose the ability to engage in activities they enjoy ( Tofthagen, 2010). The duration of CIPN symptoms ranges from months to years following treatment and may be permanent ( Miltenburg & Boogerd, 2014).

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Tofthagen C. (2010). Patient perceptions associated with chemotherapy-induced peripheral neuropathy. Clinical Journal of Oncology Nursing, 14( 3), E22–E28. 10.1188/10.CJON.E22-E28 [ PubMed] [ CrossRef] [ Google Scholar] CTCAE results: Decrease in the incidence of ≥ grade 2 peripheral neuropathy in the intervention side ( p< .0001). The occurrence of ≥ grade 2 sensory neurotoxicity decreased from 76.1% to 21.4%, and that of motor neurotoxicity decreased from 57.1% to 26.2% Pereira S., Fontes F., Sonin T., Dias T., Fragoso M., Castro-Lopes J. M., & Lunet N. (2016). Chemotherapy-induced peripheral neuropathy after neoadjuvant or adjuvant treatment of breast cancer: A prospective cohort study. Supportive Care in Cancer, 24( 4), 1571–1581. 10.1007/s00520-015-2935-y [ PubMed] [ CrossRef] [ Google Scholar] One of the two studies that applied a relatively lesser amount of cooling as defined in this review achieved statistically significant benefits in the severity of peripheral neuropathy ( Tsuyuki et al., 2016). This prospective, self-controlled study included 42 breast cancer patients who received compression therapy with two surgical gloves sized one size too small worn on the dominant hand, which resulted in a decrease in fingertip temperature on the intervention side. Subjects received nab-paclitaxel every 3 weeks for four cycles. Outcomes were measured using the CTCAE and the PNQ and were recorded at baseline, before each treatment cycle, and 1 week after nab-paclitaxel was administered. CTCAE results demonstrated a decrease in the incidence of ≥ grade 2 peripheral neuropathy on the intervention side ( p< .0001). The occurrence of ≥ grade 2 sensory neurotoxicity decreased from 76.1% to 21.4%, and that of motor neurotoxicity decreased from 57.1% to 26.2%. Patient Neuropathy Questionnaire results demonstrated significantly lower grades of peripheral neuropathy on the intervention side ( p< .0001).Pérez Fidalgo J. A., García Fabregat L., Cervantes A., Margulies A., Vidall C., & Roila F. (2012). Management of chemotherapy extravasation: ESMO-EONS Clinical Practice Guidelines. Annals of Oncology, 23( Suppl 7), vii167–vii173. 10.1093/annonc/mds294 [ PubMed] [ CrossRef] [ Google Scholar]

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Griffiths C., Kwon N., Beaumont J. L., & Paice J. A. (2018). Cold therapy to prevent paclitaxel-induced peripheral neuropathy. Supportive Care in Cancer, 26( 10), 3461–3469. 10.1007/s00520-018-4199-9 [ PubMed] [ CrossRef] [ Google Scholar] Decreased impairment on intervention side: hand tactile sensitivity (27.8% vs. 80.6%, p< .001), foot tactile sensitivity (25.0% vs 63.9%, p< .001), hand warm sense (8.8% vs. 32.4%, p = .02), foot warm sense (33.4% vs. 57.6%, p = .04), and manipulative dexterity ( p = .005) Christodoulou C., Tsakalos G., Galani E., & Skarlos D. V. (2006). Scalp metastases and scalp cooling for chemotherapy-induced alopecia prevention. Annals of Oncology, 17( 2), 350Evaluation before the start of each cycle and 3 weeks after the last chemotherapy in the regional cooling group. Retrospective data from historical cohort provided data from comparable time points Correlation between motor nerve amplitude preservation at 6 months and degree of skin cooling achieved, which demonstrated statistical significance ( p< .0005)

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Tofthagen C., Overcash J., & Kip K. (2012). Falls in persons with chemotherapy-induced peripheral neuropathy. Supportive Care in Cancer, 20( 3), 583–589. 10.1007/s00520-011-1127-7 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Seretny M., Currie G. L., Sena E. S., Ramnarine S., Grant R., MacLeod M. R.,...Fallon M. (2014). Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain, 155( 12), 2461–2470. 10.1016/j.pain.2014.09.020 [ PubMed] [ CrossRef] [ Google Scholar] Determine whether limb hypothermia is protective against paclitaxel-induced peripheral neuropathy and assess safety and tolerability Evaluate efficacy of compression with surgical gloves to prevent nanoparticle albumin-bound paclitaxel-associated peripheral neuropathy Hanai A., Ishiguro H., Sozu T., Tsuda M., Yano I., Nakagawa T.,...Tsuboyama T. (2018). Effects of cryotherapy on objective and subjective symptoms of paclitaxel-induced neuropathy: Prospective self-controlled trial. Journal of the National Cancer Institute, 110( 2), 141–148. 10.1093/jnci/djx178 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]

Measurements at baseline, 2 weeks post treatment completion, and at first, fifth, ninth, and final weekly paclitaxel treatments Mols F., Beijers T., Vreugdenhil G., & van de Poll-Franse L. (2014). Chemotherapy-induced peripheral neuropathy and its association with quality of life: A systematic review. Supportive Care in Cancer, 22( 8), 2261–2269. 10.1007/s00520-014-2255-7 [ PubMed] [ CrossRef] [ Google Scholar]

The Impact of Peripheral Cooling on Chemotherapy-Induced

Tsuyuki S., Senda N., Kanng Y., Yamaguchi A., Yoshibayashi H., Kikawa Y.,...Inamoto T. (2016). Evaluation of the effect of compression therapy using surgical gloves on nanoparticle albumin-bound paclitaxel-induced peripheral neuropathy: A phase II multicenter study by the Kamigata Breast Cancer Study Group. Breast Cancer Research in Treatment, 160( 1), 61–67. 10.1007/s10549-016-3977-7 [ PubMed] [ CrossRef] [ Google Scholar] Hershman D. L., Lacchetti C., & Loprinzi C. L. (2014). Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline Summary. Journal of Oncology Practice, 10( 6), e421–e424. 10.1200/JOP.2014.001776 [ PubMed] [ CrossRef] [ Google Scholar]Occurrence of Patient Neurotoxicity Questionnaire grades D or E peripheral neuropathy reduced with intervention (hand: 2.8% vs. 41.7%, p< .001; foot: 2.8 vs. 36.1%, p< .001) Improved preservation of sensory nerve action potential amplitude in the sural nerve. Did not achieve statistical significance ( p = .16) No statistically significant preservation of hand or foot cold sense, vibration perception, electrophysiological measurements