Immunocal

Product Information

The research lead to the development of a product called Immunocal, which is widely recognised in the medical community as being a great immune booster. Treatment vaccines, which work against cancer by boosting your immune system’s response to cancer cells. Treatment vaccines are different from the ones that help prevent disease. Droge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J: 11(13):1077-1089, 1997 Anderson said he also hoped to conduct similar experiments using antibodies harvested from people with ME/CFS and long Covid. Lomaestro B, Malone M. Glutathione in health and disease: pharmacotherapeutic issues. Ann Pharmacother 29: 1263-73,1995

The neurotoxic effects of aluminum exposure are well documented, and recently, environmental aluminum and aluminum-containing vaccines have garnered attention as potential causes of neurodegeneration. In general, in vitro exposure of neural cells to aluminum has been shown to result in pronounced alterations in mitochondrial structure and function, leading to marked increases in ROS, reduction of mitochondrial enzyme activity, and cell death [ 45]. Aluminum also interferes with the activity of NADP-isocitrate at the mitochondria, decreasing the pool of NADPH that is available and necessary for the regeneration of GSH, and thereby decreasing GSH levels [ 61]. In vivo examination of aluminum neurotoxicity has demonstrated that healthy mice treated with aluminum hydroxide display significant motor deficits and develop pathological features similar to those observed in ALS [ 62]. These results are notable in that Veterans of the 1990-1991 Gulf War who received vaccines containing aluminum hydroxide adjuvant demonstrate a significant increase in the incidence of ALS, implicating aluminum toxicity as one potential environmental factor in some forms of sporadic ALS [ 62, 63]. Our experiments clearly demonstrate that Immunocal pretreatment is capable of significantly reducing the degree of neurotoxicity observed with aluminum in CGN cultures. We further confirmed that the protective effects of Immunocal were not due to metal chelation by removing Immunocal-containing media prior to the addition of AlCl 3.

IMMUNOCAL

Other effects have also been noted – such as effects on gaining muscle strength, prevention of bone loss, and reduction of inflammation. This lead to a second product called Immunocal Platinum which was formulated for athletes and the very frail. A broad Spectrum of Vitamins and Minerals are supplied at the correct levels to help support strong development and growth. The internet is peppered to reprints of this research in ads, journals, press releases etc, so it is certainly popular. It is also fairly singular and seems to be on a pedestal on its own.

Ovarian cancer. One monoclonal antibody is available now. But many immunotherapy trials are underway for this type of deadly cancer. Locigno R, Castronovo V. Reduced glutathione System: Role in cancer development, prevention and treatment. International Journal of Oncology 19:221-236, 2001

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Monoclonal antibodies, which are immune system proteins created in the lab that are designed to bind to specific targets on cancer cells. Some monoclonal antibodies mark cancer cells so that they will be better seen and destroyed by the immune system. Such monoclonal antibodies are a type of immunotherapy. Gastrointestinal bloating and cramps if not sufficiently rehydrated. Transient urticarial-like rash in rare individuals undergoing severe detoxification reaction. Rash abates when product intake stopped or reduced. Overdosage The American Diabetes Association (ADA) releases updated Standards of Medical Care in Diabetes every year in January [ 24]. Recent updates have focused on individualization of diabetes management in screening, intervention and care, use of technology, and prevention of complications [ 25]. Patient-centered care goals were emphasized in preventing type 2 DM. Overweight and obese adults at high-risk of type 2 DM are recommended to be referred to an intensive lifestyle and behavior change program. Individualized management of overweight and obese adults was also emphasized to prevent diabetes and comorbidities [ 26]. With developments of technology, it was recommended to consider technological assistance according to the individual’s preference [ 27]. Given the prominent relationship between GSH depletion and neurodegeneration, it is not surprising that many studies have been undertaken to determine the neuroprotective effects of bolstering GSH levels through various treatment paradigms. Such treatments include administration of the GSH precursor, N-acetylcysteine (NAC), and GSH-monoethylester (GSH-MEE), a cell permeable form of GSH, and induction of the transcription factor, nuclear factor erythroid 2-related factor-2 (Nrf2), which is involved in transcriptional regulation of γ-glutamyl-cysteine ligase, the rate-limiting enzyme necessary for GSH synthesis [ 19]. Studies with NAC are extensive and indicate that NAC treatment offers a number of benefits across numerous disease models. For example, NAC demonstrated a significant protective capacity in a rotenone (complex I inhibition) rat model of Parkinson's disease by decreasing ROS generation, sustaining normal GSH levels, and ultimately preventing dopaminergic cell death [ 20]. In the G93A mutant SOD1 mouse model of familial ALS, NAC delayed the onset of disease-associated motor deficits and significantly extended survival, possibly due to its ability to elevate GSH levels in these animals [ 21]. Lastly, SAMP8 senescence-accelerated mice, which display many of the pathological features of Alzheimer's disease, demonstrated an increased cognitive performance with NAC treatment as compared to vehicle-treated controls [ 22]. Another study utilizing GSH-MEE in an MPTP rat model of Parkinson's disease demonstrated that GSH-MEE supplementation is capable of raising GSH levels in the brain when centrally delivered, and this increase in GSH corresponded to partial preservation of striatal dopamine levels [ 23]. Studies such as this have led to recent clinical trials testing the safety and tolerability of intranasal delivery of GSH to patients with PD [ 24]. Finally, Nrf2 induction or overexpression has shown similar promise in animal models of Parkinson's, ALS, and Alzheimer's disease. In the MPTP mouse model of Parkinson's disease, overexpression of Nrf2 in astrocytes attenuated the development of a Parkinsonian phenotype [ 25]. Likewise, astrocytic overexpression of Nrf2 in a mouse model of ALS both delayed onset and increased survival, as did treatment with chemical Nrf2 inducers [ 26, 27]. Comparatively, lentiviral Nrf2 overexpression caused significant improvements in observed learning deficits in a mouse model of Alzheimer's disease, accompanied by decreased amyloid plaque burden [ 28]. Cumulatively, these data indicate that treatments aimed at increasing GSH levels in the brain may be a viable option for treatment and prevention of neurodegenerative disease.

Andersson and his colleagues harvested blood from 44 people with fibromyalgia and injected purified antibodies from each of them into different mice. The mice rapidly became more sensitive to pressure and cold, and displayed reduced grip strength in their paws. Animals injected with antibodies from healthy people were unaffected. Bounous G, Kongshavn P. Influence of protein type in nutritionally adequate diets on the development of immunity. In Absorption and Utilization of Amino Acids Vol.II. Ed. M. Friedman. CRC Press, Inc., Fla. 2:219-32, 1989 Bounous G. Immunoenhancing properties of undenatured milk serum protein isolate in HIV patients. Int. Diary Fed: Whey: 293-305, 1998 Immunotherapy is a cancer treatment that helps your own immune system beat cancer. That’s different than traditional chemotherapy, which uses drugs that kill both cancer and healthy cells. Nucleotides are critical for cellular development and also crucial in the development of the immune system.Proposed neuroprotective mechanism of Immunocal. Immunocal provides the essential GSH precursor, cystine, which is transported into cerebellar granule neurons via the system x c − antiporter (Sx c −). Upon entry into the cell, cystine is rapidly hydrolyzed to form two cysteine molecules, which are then utilized in the de novo synthesis of GSH by γ-glutamylcysteine ligase ( γ-GCL) and glutathione synthase (GSS). Newly synthesized glutathione inhibits oxidation caused by a variety of insults, thereby preventing mitochondrial oxidative stress (MOS) and subsequent induction of apoptosis. Dr Jim McCallum, “… when I first heard about Immunocal I wasn’t very interested. When I finally read the clinical studies about Immunocal and realised how this product worked on optimising the immune system response, I felt strongly that this product was going to have a major impact on the health profession…having seen such dramatic health results of those people on it.” The human body and its individual cells are protected from the ravages of oxidation by ‘antioxidants’. While many are aware of vitamins A, C and E being anti-oxidants, the most important is a substance called glutathione.