Sample did not arrive at the laboratory as specified in the specimen transport and storage section of the FASP handbook. The numerator and denominator exclude congenitally corrected transposition of the great arteries ( TGA). The programme-specific operating model for quality assurance of the FASP programme should be read in conjunction with the latest SQAS operating model and the relevant programme standards. Down’s syndrome quality assurance support service

The chance cut-off is set at 1 in 150 at term for the combined and quadruple tests. This means women with a result of greater than or equal to 1 in 150 (between 1 in 2 and 1 in 150) are in the higher chance group. These women must be offered an appointment to discuss their results and the option of prenatal diagnosis. The appointment can be face to face or virtual depending on the woman’s choice. The quadruple test is offered in the second trimester to assess the chance of the baby having Down’s syndrome. Please be aware that this data covers the time period through the COVID-19 pandemic. Provider performance should therefore be interpreted with caution.

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present to the service at or after 23 weeks plus 1 day (as they are not part of the eligible population for the screening programme) Women who decline is the number of eligible women who are offered screening and make a personal informed choice not to accept screening, including women who choose to have private screening and do not wish to have NHS screening. Standard S08a excludes women with a suspected or confirmed fetal anomaly where a referral is required to a tertiary fetal medicine centre for further investigation and care (as clinically appropriate as per local pathway).

Numerator: number of confirmed cytogenetic diagnoses of T21 following a higher chance T21 result from the combined test move ‘women who choose to have private screening and do not wish to have NHS screening’ to the subset of declines National performance of NB2 (see standard NBS-S06) in Q2 was 2.2%, similar to the previous quarter. The trend graph below shows that England NB2 performance is above the acceptable threshold of 2%. NB2 is a KPI where a lower performance is better. Annually by 30 September for women who book with an estimated date of delivery within the previous financial year (1 April to 31 March). Review datesNational performance of FA2 in Q1 2020 to 2021 was 99.3%, the highest ever level recorded for this key performance indicator (KPI0. FA2 is collected 6 months (2 quarters) in arrears. The national trend graph below shows that FA2 performance has remained above the achievable threshold of 95% since 1 April 2017. To provide assurance that individuals with higher chance results are referred in a timely manner and receive timely intervention where appropriate. Definition To provide assurance that women with a suspected or confirmed unexpected finding are referred in a timely manner and receive timely intervention where appropriate. Definition

Date standard updated: April 2022. FASP-S05: test: turnaround time T21, T18, T13 screening Description This standard is now called FASP-S03: diagnosis or intervention: test turnaround time quantitative fluorescence-polymerase chain reaction ( QF-PCR). Please be aware that this data covers the period through the coronavirus (COVID-19) pandemic. Provider performance should therefore be interpreted with caution.This standard provides assurance that the screen positive rate for the national programme remains within the defined range to minimise the number of women requiring an offer of an invasive diagnostic test. Definition

This is one of the standards we had to renumber but you will remember it as the old FASP-S09. This revised standard will look at test turnaround times for QF-PCR testing only. In Q4 2021 to 2022, national performance of FA4 for inadequate combined samples was 4.1%. FA4 is a KPI where a lower performance is better. In both standards, the exclusion ‘women who choose to have private screening and do not wish to have NHS screening’ was moved to the subset of declines. This is because women who have had private screening are still eligible for, and should be offered, NHS FASP screening.Numerator: number of confirmed cytogenetic diagnoses of T21, T18, T13 following a higher chance T21, T18, T13 result from the combined test