Having more than 50 moles indicates an increased risk in melanoma might arise. A weakened immune system makes cancer development easier due to the body's weakened ability to fight cancer cells. [18] UV radiation [ edit ]

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John Hunter is reported to be the first to operate on metastatic melanoma in 1787. Although not knowing precisely what it was, he described it as a "cancerous fungous excrescence". The excised tumor was preserved in the Hunterian Museum of the Royal College of Surgeons of England. It was not until 1968 that microscopic examination of the specimen revealed it to be an example of metastatic melanoma. [159]Nodularni melanom se obično prezentira kao brzorastući tvrdi čvorić koji u nekim slučajevima može i krvariti. Iako je najčešće tamnosmeđe do crne boje, može biti i bez pigmenta (boje kože) te crvenkaste, tamnoplave ili sivkaste boje. Ovaj tip melanoma se može razviti iz već postojećeg madeža ili na prethodno nepromijenjenoj koži. LENTIGO MALIGNA MELANOM A (od eng. asimmetry ; asimetrija) – kakvog je oblika kožna promjena? Većina melanoma su asimetričnog oblika, što znači da im dvije polovice nisu zrcalnog izgleda (jednake), dok su normalni madeži najčešće pravilnog ovalnog ili okruglog oblika. Schwartzman RM, Orkin M (1962). A Comparative Study of Diseases of Dog and Man. Springfield, IL: Thomas. p.85. The term 'melanoma' in human medicine indicates a malignant growth; the prefix 'malignant' is redundant. Having multiple severe sunburns increases the likelihood that future sunburns develop into melanoma due to cumulative damage. [18] The sun and tanning beds are the main sources of UV radiation that increase the risk for melanoma [32] and living close to the equator increases exposure to UV radiation. [18] Genetics [ edit ]

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Melanoma Global Coalition. For a second year, Melanoma UK is proudly supporting the 2020 global public awareness campaign in the fight against melanoma. Radiation therapy is often used after surgical resection for patients with locally or regionally advanced melanoma or for patients with un-resectable distant metastases. Kilovoltage x-ray beams are often used for these treatments and have the property of the maximum radiation dose occurring close to the skin surface. [142] It may reduce the rate of local recurrence but does not prolong survival. [143] Radioimmunotherapy of metastatic melanoma is currently under investigation. a b Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, etal. (GBD 2015 Mortality Causes of Death Collaborators) (October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi: 10.1016/s0140-6736(16)31012-1. PMC 5388903. PMID 27733281. One involved lymph node, or any number of in-transit, satellite, and/or microsatellite metastases with no tumor-involved nodes. Biopsy of sentinel lymph nodes is a widely used procedure when treating cutaneous melanoma. [112] [113]a b Azoury SC, Lange JR (October 2014). "Epidemiology, risk factors, prevention, and early detection of melanoma". The Surgical Clinics of North America. 94 (5): vii, 945–62. doi: 10.1016/j.suc.2014.07.013. PMID 25245960. Pregledavajte svoju kožu temeljito barem jednom mjesečno, a jednom godišnje posjetite dermatologa. Pripazite na bilo kakve novonastale pigmentirane promjene, osobito ako su neobičnog izgleda i boje ili ako se mijenjaju s vremenom. Također, pripazite i na promjene već postojećih madeža. U slučaju da uočite bilo što sumnjivo, odmah se javite liječniku. Ako vam dermatolog na pregledu napomene da je neke madeže potrebno pratiti, pratite njegova uputstva i redovito kontrolirajte takve promjene. I naravno, ne zaboravite na tjelesnu aktivnost, pravilnu i raznovrsnu prehranu te izbjegavanje štetnih čimbenika poput pušenja i alkohola, kako biste održavali svoj imunološki sustav jakim i učinkovitim u borbi protiv bolesti.